Circulating Spike Protein in Blood of Vaccinated Long-COVID Patients

covid and vaccines

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Strong Rationale for Empiric Base Spike Detox Regimen

Approximately 15% of patients took one or more injections of COVID-19 vaccine products and now have had COVID-19 illness and are suffering from persistent symptoms or new medical diseases.

Of those ~94% received mRNA in Pfizer or Moderna products. Several studies have show that symptoms after COVID-19, most of whom also had baseline or subsequent vaccination, are directly related to persistent circulating Spike protein.

Swank et al, from Harvard University, found circulating Spike protein and or nucleocapsid in the blood of 65% of patients with long-COVID symptoms (post-acute sequelae symptoms) some of whom were unfortunately vaccinated even after being sick.

These data imply the symptoms are driven by persistent fragments of the SARS-CoV-2 virus and Spike protein from repeated injections.

Swank Z, Senussi Y, Manickas-Hill Z, Yu XG, Li JZ, Alter G, Walt DR. Persistent Circulating Severe Acute Respiratory Syndrome Coronavirus 2 Spike Is Associated With Post-acute Coronavirus Disease 2019 Sequelae. Clin Infect Dis. 2023 Feb 8;76(3):e487-e490. doi: 10.1093/cid/ciac722. PMID: 36052466; PMCID: PMC10169416.

Base Spike Detox (BSD) is an empiric regimen designed to assist the body in breaking down the Spike protein and allowing natural clearance of protein fragments through the reticuloendothelial system. All three components have considerable support from the preclinical and clinical literature. Other agents can be added including N-acetylcysteine, but they should not be substituted for these three as the base of treatment (3-12+ months):


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  • Nattokinase 2000 FU (100 mg) orally twice daily
  • Bromelain 500 mg orally once daily
  • Curcumin (nano- liposomal +piperine 10 mg) 500 mg orally twice daily

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About the Author

Dr Peter McCullough
Dr. Peter A. McCullough brings truth to the world and fight battles against censorship and reprisal. He is an internist, cardiologist, epidemiologist, and the Chief Scientific Officer of The Wellness Company. Since the outset of the pandemic, Dr. McCullough has dozens of peer-reviewed publications on the infection and has commented extensively on the medical response to the COVID-19 crisis. Dr. McCullough is one of the most published cardiologist ever in America, with over 1,000 publications and 660 citations in the National Library of Medicine and is a recipient of the Simon Dack Award from the American College of Cardiology and the International Vicenza Award in Critical Care Nephrology for his scholarship and research.